کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8320822 1539406 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways
چکیده انگلیسی
Human TopBP1 contains nine BRCT domains and functions in DNA replication initiation, checkpoint signalling, DNA repair and influences transcriptional control. TopBP1 and its homologues have been the subject of numerous scientific publications since the last comprehensive review in 2005, emerging as a key scaffold protein that links crucial components within these distinct cellular processes. This review focuses on recently published work, with particular emphasis on structural insights into TopBP1 function and the binding partners identified for DNA replication initiation, DNA-dependent checkpoints, DNA repair and transcription. We further summarise what is known about TopBP1 and links to human disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 22, October 2014, Pages 165-174
نویسندگان
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