کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8320943 1539409 2014 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research
چکیده انگلیسی
Why does a constant barrage of DNA damage lead to disease in some individuals, while others remain healthy? This article surveys current work addressing the implications of inter-individual variation in DNA repair capacity for human health, and discusses the status of DNA repair assays as potential clinical tools for personalized prevention or treatment of disease. In particular, we highlight research showing that there are significant inter-individual variations in DNA repair capacity (DRC), and that measuring these differences provides important biological insight regarding disease susceptibility and cancer treatment efficacy. We emphasize work showing that it is important to measure repair capacity in multiple pathways, and that functional assays are required to fill a gap left by genome wide association studies, global gene expression and proteomics. Finally, we discuss research that will be needed to overcome barriers that currently limit the use of DNA repair assays in the clinic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 19, July 2014, Pages 199-213
نویسندگان
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