کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8321981 | 1539843 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular mechanisms underlying TGF-Ã/Hippo signaling crosstalks - Role of baso-apical epithelial cell polarity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Molecular mechanisms underlying TGF-Ã/Hippo signaling crosstalks - Role of baso-apical epithelial cell polarity Molecular mechanisms underlying TGF-Ã/Hippo signaling crosstalks - Role of baso-apical epithelial cell polarity](/preview/png/8321981.png)
چکیده انگلیسی
The ubiquitous distribution of both Hippo and TGF-Ã signaling cascade components and their critical implication in tissue homeostasis and disease has led to the discovery of a remarkable slew of interesting and unique features regarding their functional crosstalks. Upstream cellular cues regulating the Hippo pathway, including cell-cell contacts and apico-basal cell polarity have been well characterized. Herein, we provide an overview of the published models of compartmentalized signaling crosstalk mechanisms between Hippo signaling and the TGF-Ã/SMAD pathway. How cell polarity impacts the interaction between the two pathways is discussed, together with the specifics of cytoplasmic and nuclear events implicating SMADs and YAP/TAZ, leading to contextual regulation of target gene expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 98, May 2018, Pages 75-81
Journal: The International Journal of Biochemistry & Cell Biology - Volume 98, May 2018, Pages 75-81
نویسندگان
Saber Ben Mimoun, Alain Mauviel,