Assessment of pro-apoptotic activity of doxorubicin-transferrin conjugate in cells derived from human solid tumors

- DOX-TRF conjugate induces caspase-dependent apoptosis in cancer cells at a low dose.
- Human tumor cells are more sensitive to DOX-TRF conjugate application than DOX alone.
- DOX-TRF conjugate shows a higher level of pro-apoptotic DNA damage than free DOX.