کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8322511 | 1539875 | 2015 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular behavior of human Mrt4 protein, MRTO4, in stress conditions is regulated by its C-terminal region
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Molecular behavior of human Mrt4 protein, MRTO4, in stress conditions is regulated by its C-terminal region Molecular behavior of human Mrt4 protein, MRTO4, in stress conditions is regulated by its C-terminal region](/preview/png/8322511.png)
چکیده انگلیسی
Protein Mrt4 is one of trans-acting factors involved in ribosome biogenesis, which in higher eukaryotic cells contains a C-terminal extension similar to the C-terminal part of ribosomal P proteins. We show that human Mrt4 (hMrt4/MRTO4) undergoes phosphorylation in vivo and that serines S229, S233, and S235, placed within its acidic C-termini, have been phosphorylated by CK2 kinase in vitro. Such modification does not alter the subcellular distribution of hMrt4 in standard conditions but affects its molecular behavior during ActD induced nucleolar stress. Thus, we propose a new regulatory element important for the stress response pathway connecting ribosome biogenesis with cellular metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 69, December 2015, Pages 233-240
Journal: The International Journal of Biochemistry & Cell Biology - Volume 69, December 2015, Pages 233-240
نویسندگان
Barbara Michalec-Wawiorka, Leszek Wawiorka, Kamil Derylo, Dawid Krokowski, Aleksandra Boguszewska, Eliza Molestak, Monika Szajwaj, Marek Tchorzewski,