Overexpressed GRP78 affects EMT and cell-matrix adhesion via autocrine TGF-β/Smad2/3 signaling

- GRP78 facilitates cell-ECM adhesion by induce activation of fibronectin-integrin-β1-FAK signaling pathway.
- GRP78 induced cell-cell dissociation and EMT.
- Snail-2 plays the key role in GRP78 mediated adhesion switch and EMT.
- GRP78 promoted the expression and secretion of TGF-β1, and activated downstream TGF-β/Smad signaling pathway.