Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease

- We show a developmental isoform switch of COX6A/COX7A in muscle of humans and mice.
- Liver isoforms are present at birth; heart/muscle isoforms increase ∼3 months of age.
- The physiological isoform switch does not explain reversible mitochondrial disease.
- Developmental changes of COX isoforms may modify other mitochondrial diseases.