Involvement of the AMPK-PTEN pathway in insulin resistance induced by high glucose in cultured rat podocytes

- Impairment by high glucose of insulin-induced glucose uptake is AMPK dependent.
- AMPKα subunits (1 and 2) are both required for insulin induction of glucose uptake.
- Insulin resistance of podocytes is accompanied by increased PTEN protein levels.
- AMPK-PTEN pathway may be involved in regulation of insulin activity in podocytes.