Deoxypodophyllotoxin exerts both anti-angiogenic and vascular disrupting effects

- The anti-angiogenic and vascular disrupting activities of deoxypodophyllotoxin (DPT) were identified.
- DPT-induced cytoskeleton reorganization is likely contributed to the anti-angiogenic effect.
- The mechanism of DPT-induced G2/M arrest might involve the dysregulation of cyclin B1 and p21.
- DPT exerts the vascular disrupting activity likely via Rho/Rho kinase pathway.