کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8324507 | 1539912 | 2012 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human epithelial cells stimulated with Vibrio cholerae produce thymic stromal lymphopoietin and promote dendritic cell-mediated inflammatory Th2 response
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کلمات کلیدی
TSLPRTSLPGM-CSFDCsG3PDHTSLP receptorLPSSIgGECs - EC هاERK1/2 - ERK1 / 2MAPK - MAPKMOI - MEimmunoglobulin G - ایمونوگلوبولین Ginterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینTER - داشتنepithelial cells - سلول بافت پوششی یا اپیتلیومDendritic cells - سلول های دندریتیکcholera toxin - سوزش گوارشیgranulocyte–macrophage colony-stimulating factor - عامل گرانولوسیت-ماکروفاژ colony-stimulating factorThymic stromal lymphopoietin - لنفوپیتین استروما تیمیکLipopolysaccharides - لیپوپلی ساکارید هاTransepithelial resistance - مقاومت TransepithelialVibrio cholerae - ویبریو کلراmultiplicity of infection - چندین عفونتextracellular signal-regulated kinases - کیناز های تنظیم شده سیگنال خارج سلولیglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Vibrio cholerae induces acute inflammatory response at intestinal epithelial surface; the underlying cellular immune mechanisms for such effects are largely unexplored. Mucosal immune response is controlled by crosstalk between the intestinal epithelial cells (ECs) and dendritic cells (DCs). An EC-derived cytokine thymic stromal lymphopoietin (TSLP) has been found a critical regulator of several human inflammatory conditions. TSLP is highly elevated in ECs stimulated with V. cholerae and its recombinant flagellin (rFlaA). V. cholerae treated human ECs produce DC-attracting chemokine MIP-3α (CCL20). Flagellin, a potent V. cholerae factor was responsible for maximum stimulation of epithelial CCL20 production and subsequent DC activation. Activated DCs express high levels of costimulatory molecules and secrete inflammatory cytokines TNF-α, IL-6 and IL-1β. Bacteria stimulated ECs conditioned DCs to produce Th2 cell-attracting chemokines CCL17 and CCL22. TSLP and other mediators present in the V. cholerae stimulated EC-culture filtrate potently activated DCs, which subsequently primed CD4+T cells to differentiate into T helper type 2 (Th2) cells that produce high amounts of IL-4, IL-13 and TNF-α and low IFN-γ. TSLP-induced proinflammatory response in DCs involved the transcriptional mechanisms, MAPKs (ERK1/2, p38 and JNK) and STAT3 activation. This study suggests TSLP and other mediators released from ECs in response to V. cholerae colonization actively influence DCs in initiating inflammatory response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 44, Issue 11, November 2012, Pages 1779-1790
Journal: The International Journal of Biochemistry & Cell Biology - Volume 44, Issue 11, November 2012, Pages 1779-1790
نویسندگان
Swati Bhowmick, Debashree Chatterjee, Keya Chaudhuri,