Mechanisms elevating ORMDL3 expression in recurrent wheeze patients: Role of Ets-1, p300 and CREB

► ORMDL3 expression was significantly increased in recurrent wheeze patients compared with normal control subjects. ► Transcriptional activity of ORMDL3 gene was dependent on Ets-1, p300 and CREB transcription factor. ► The expression levels of Ets-1, p300 and CREB were increased in recurrent wheeze patients compared with normal control subjects.