کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8325595 | 1539948 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Salmonella Typhimurium: Insight into the multi-faceted role of the LysR-type transcriptional regulators in Salmonella
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The LysR-type transcriptional regulators (LTTRs) are widely distributed in various genera of prokaryotes. LTTRs are DNA binding proteins that can positively or negatively regulate target gene expression and can also repress their own transcription. Salmonella enterica comprises a group of Gram-negative bacteria capable of causing clinical syndromes that range from self-limiting diarrhoea to severe fibrinopurulent necrotizing enteritis and life threatening systemic disease. The survival and replication of Salmonella in macrophages and in infected host is brought about by the means of various two component regulatory systems, transporters and other virulence islands. In Salmonella genome the existence of 44 LTTRs has been documented. These LTTRs regulate bacterial stress response, systemic virulence in mice and also many virulence determinants in vitro. Here we focus on the findings that elucidate the structure and function of the LTTRs in Salmonella and discuss the importance of these LTTRs in making Salmonella a successful pathogen.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 41, Issue 11, November 2009, Pages 2129-2133
Journal: The International Journal of Biochemistry & Cell Biology - Volume 41, Issue 11, November 2009, Pages 2129-2133
نویسندگان
Amit Lahiri, Priyanka Das, Dipshikha Chakravortty,