کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8326050 | 1539955 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The soluble transforming growth factor-β receptor: Advantages and applications
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Transforming growth factor-beta (TGF-β) is a cytokine that plays a pivotal role in growth, differentiation, development, immune response and wound healing. TGF-β is upregulated following wound infliction and inflammation, and plays an important role in the production of extracellular matrix proteins that contribute to tissue repair. However, in some diseases, TGF-β dysregulation can lead to tumor formation, organ fibrosis and the disruption of organ function. A number of molecules have been designed to counteract the effects of TGF-β, including anti-TGF-β monoclonal antibodies and various small molecules. Here we discuss the design, use and advantages of the highly specific TGF-β binding molecule, the soluble human TGF-β receptor (sTβR.Fc) as a TGF-β sequestering agent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 41, Issue 3, March 2009, Pages 472-476
Journal: The International Journal of Biochemistry & Cell Biology - Volume 41, Issue 3, March 2009, Pages 472-476
نویسندگان
Leileata M. Russo, Dennis Brown, Herbert Y. Lin,