کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8326263 | 1539965 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MscS, the bacterial mechanosensitive channel of small conductance
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: MscS, the bacterial mechanosensitive channel of small conductance MscS, the bacterial mechanosensitive channel of small conductance](/preview/png/8326263.png)
چکیده انگلیسی
The mechanosensitive channel of small conductance, MscS, is one of the most extensively studied MS channels to date. Past and present research involves the discovery of its physiological role as an emergency valve in prokaryotes up to detailed investigations of its conductive properties and gating mechanism. In this review, we summarize the findings on its structure and function obtained by experimental and theoretical approaches. A special focus is given to its pharmacology, since various compounds have been shown to affect the activity of this channel. These compounds have particularly been helpful for understanding the interaction of MscS with the lipid bilayer, as well as recognizing the potential of this channel as a target for novel types of antibiotics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 40, Issue 4, 2008, Pages 581-585
Journal: The International Journal of Biochemistry & Cell Biology - Volume 40, Issue 4, 2008, Pages 581-585
نویسندگان
Annette C. Hurst, Evgeny Petrov, Anna Kloda, Thom Nguyen, Livia Hool, Boris Martinac,