کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8326636 | 1540195 | 2018 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Drug-loaded poly(L-lactide)/lignin stereocomplex film for enhancing stability and sustained release of trans-resveratrol
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Drug-loaded poly(L-lactide)/lignin stereocomplex film for enhancing stability and sustained release of trans-resveratrol Drug-loaded poly(L-lactide)/lignin stereocomplex film for enhancing stability and sustained release of trans-resveratrol](/preview/png/8326636.png)
چکیده انگلیسی
We report a new drug-loaded film for blending poly(L-lactide) (PLLA) with lignin-based functional filler, which enhanced stability and sustained release of trans-resveratrol (trans-RSV). In addition, trans-RSV loaded PLLA/lignin films showed good antioxidant and anticancer effects. Incorporation of the optimized amount of lignin-based filler to PLLA matrix was key to achieve these desired functions. The lignin-based filler (LG-g-PDLA) was synthesized via ring-opening polymerization on alklin lignin with D-lactide. Benifiting from the stereocomplex formation (PLLA and PDLA side chains), similar polyphenolic structures between lignin and trans-RSV, and UV chromophoric groups of lignin, trans-RSV loaded PLLA/lignin-graft-PDLA films (R/P/LGPD) have good performances on mechanical property, uniformity distribution of drug, and light barrier property. The release behaviors of trans-RSV could be controlled by variation of LG-g-PDLA content. This system therefore offers great potential for the delivery of poor water soluble and light stability drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 119, November 2018, Pages 1129-1136
Journal: International Journal of Biological Macromolecules - Volume 119, November 2018, Pages 1129-1136
نویسندگان
Rui Liu, Lin Dai, Zhufan Zou, Chuanling Si,