کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8326792 | 1540195 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carboxymethylcellulose capsulated Cu-based metal-organic framework-drug nanohybrid as a pH-sensitive nanocomposite for ibuprofen oral delivery
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Due to non-invasive nature of oral delivery and the fact that avoids patient pain and discomfort, so the oral method is one of the most commonly used. By consideration this aim, Cu-based metal-organic framework encapsulated ibuprofen (IBU) drug nanohybrid (Cu-MOF@Drug) protected with pH-sensitive biopolymeric carboxymethylcellulose (CMC) as a novel nanocomposite for oral delivery system was synthesized. The prepared hydrogel bead characterized using FT-IR, BET, XRD, UV-Vis spectroscopy and SEM analysis. The drug release tests showed that the CMC capsulated Cu-MOF@IBU nanocomposite hydrogel bead (CMC/Cu-MOF@IBU) has a better protection against stomach pH and extended the stability of drug dosing indeed it provides a controlled release in the gastrointestinal tract conditions. The MTT test demonstrated that the CMC/Cu-MOF@IBU has low toxicity against Caco-2 cells. According to the obtained results, the hydrogel bead could potentially use as an oral drug delivery system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 119, November 2018, Pages 588-596
Journal: International Journal of Biological Macromolecules - Volume 119, November 2018, Pages 588-596
نویسندگان
Siamak Javanbakht, Malihe Pooresmaeil, Hamed Hashemi, Hassan Namazi,