کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8327103 1540198 2018 27 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation of bergenin - Poly (lactic acid) polymers and in vitro controlled release studies
ترجمه فارسی عنوان
آماده سازی پلیمرهای برگرین - پلی (اسید لاکتیک) و مطالعات آزمایشی کنترل شده در آزمایشگاهی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
The efficacy of bergenin prepared with osmotic-pump-controlled release is much lower than expected. In this study, biodegradable polylactic acid is used to modify bergenin and immobilize it with chemical methods. Bergenin-PLA obtained by this method has low molecular weight and good thermal stability, as well as prolonged in vitro release time along with increased molecular weight. Biocompatibility tests and in vitro antitumor tests showed that bergenin-PLA at a ratio of 1:30 has good biological properties and low cytotoxicity at t three concentrations, and its antitumor activity was significantly increased compared to bergenin. The chemical immobilization of bergenin not only provides a good mode of administration for patients but also provides a good foundation for the sustained release of drugs over time.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 116, September 2018, Pages 354-363
نویسندگان
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