کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8327956 | 1540204 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metabonomic profiling in study hepatoprotective effect of polysaccharides from Flammulina velutipes on carbon tetrachloride-induced acute liver injury rats using GC-MS
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
This study was performed to evaluate the hepatoprotective effect of FVP on carbon tetrachloride induced acute liver injury rats. Transaminase levels, antioxidant effect and histopathology were used to assess the recovery of FVP treated acute liver injury rats. Metabolomic analysis of liver homogenate based on GC-MS was used to obtain a global understanding of metabolic change between acute liver injury model rats and FVP-treated rats in order to assess the underlying mechanisms. Multivariate statistical approaches such as principal component analysis and orthogonal projection to latent structure square-discriminant analysis revealed distinctions among the normal, liver injury model, and FVP groups. The results demonstrated that FVP had a hepatoprotective effect on acute liver injury by decreasing AST and ALT levels, enhancing antioxidant effect and attenuating pathological injury. Sixteen metabolites were identified as biomarkers. These biomarkers belonged to glyoxylate and dicarboxylate metabolism, galactose metabolism, glycine, serine and threonine metabolism, glycerolipid metabolism, alanine, aspartate and glutamate metabolism, TCA cycle, pyruvate metabolism, arginine and proline metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 110, 15 April 2018, Pages 285-293
Journal: International Journal of Biological Macromolecules - Volume 110, 15 April 2018, Pages 285-293
نویسندگان
Yan Zhang, Haitao Li, Tao Hu, Hui Li, Gang Jin, Yang Zhang,