کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8328072 | 1540204 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation and characterization of three-dimensional scaffolds based on hydroxypropyl chitosan-graft-graphene oxide
ترجمه فارسی عنوان
تهیه و طبقه بندی داربست های سه بعدی بر اساس هیدروکسی پروپیل کیتوزان گرافت گرافن اکسید
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کلمات کلیدی
کیتوزان، اکسید گرافن، داربست، مهندسی بافت، سمیت مسمومیت،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Hydroxypropyl chitosan (HPCH), a water soluble derivative of chitosan, is widely considered for tissue engineering and wound healing applications due to its biocompatibility and biodegradability. Graphene oxide (GO) is a carbon-based nanomaterial which is capable of imparting desired properties to the scaffolds. Hence, the integration of GO into HPCH could allow for the production of HPCH-based scaffolds with improved swelling character, mechanical strength, and stability aimed at being used in tissue engineering. In this study, hydroxypropyl chitosan-graft-graphene oxide (HPCH-g-GO) with varying GO content (0.5, 1, 3 and 4Â wt.%) was prepared using HPCH and GO as a tissue engineering scaffold material. The formation of HPCH-g-GO was confirmed by FTIR and XRD analysis. Using the HPCH-g-GO as a matrix material and glutaraldehyde as a crosslinking agent, the three dimensional (3D) porous scaffolds were fabricated by the freeze-drying method. The HPCH-g-GO scaffolds exhibited uniform porosity as observed in SEM analysis. The pore size and porosity reduced as the content of GO was increased. These scaffolds presented good swelling capacity, water retention ability, mechanical strength and in vitro degradation properties. The HPCH-g-GO scaffolds irrespective of their GO content demonstrated good cell viability when compared to control. Altogether, these results suggest that HPCH-g-GO scaffolds can be used as potential tissue engineering material.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 110, 15 April 2018, Pages 522-530
Journal: International Journal of Biological Macromolecules - Volume 110, 15 April 2018, Pages 522-530
نویسندگان
P.R. Sivashankari, A. Moorthi, K.Mohamed Abudhahir, M. Prabaharan,