کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8328990 | 1540207 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Basil polysaccharide attenuates hepatocellular carcinoma metastasis in rat by suppressing H3K9me2 histone methylation under hepatic artery ligation-induced hypoxia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Hepatocellular carcinoma (HCC) is one of the most common and fatal cancers in the world. Tumor metastasis is an important factor of poor prognosis in patients with HCC. Tumor hypoxia can promote tumor cell metastasis in HCC. Epigenetic modification is closely related to tumor hypoxia and metastasis. In our previous research, we found that basil polysaccharide suppressed migration and invasion of HCC cell by inhibiting hypoxia induced histone methylation in vitro. In the present study, we investigated the effect of basil polysaccharide on the walker 256 carcinoma cell metastasis in rat. We established an intratumoral hypoxic model in rat by hepatic artery ligation (HAL). Then rats were treated with basil polysaccharide (75, 150 and 300 mg/kg). The results showed that HAL could promote tumor metastasis by aggravating tumor hypoxia. However, basil polysaccharide could inhibit tumor metastasis in intratumoral hypoxia. Further, we demonstrated that basil polysaccharide could down-regulate the expression of HIF-1α, G9a, LSD1, JMJD1A, JMJD2B, JARID1 B and H3K9me2. Synchronously, basil polysaccharide could increase E-cadherin and VMP1 expression, and decrease N-cadherin, vimentin and β-catenin expression. The results indicated that histone modifying enzymes might be a new therapeutic target of basil polysaccharide on hepatocellular carcinoma metastasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 107, Part B, February 2018, Pages 2171-2179
Journal: International Journal of Biological Macromolecules - Volume 107, Part B, February 2018, Pages 2171-2179
نویسندگان
Bing Feng, Ying Zhu, Zuqing Su, Lipeng Tang, Chaoyue Sun, Caiyun Li, Guangjuan Zheng,