کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8329564 1540212 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity
چکیده انگلیسی
Polysaccharides derived from Sargassum thunbergii were prepared to investigate the structure-activity relationship between polysaccharides and anti-tumor activity in vitro. Many factors were examined. Overall, STW (polysaccharide extracted by hot water) had the best activity, followed by STJ (polysaccharide extracted by dilute alkali), and then STA (polysaccharide extracted by dilute acid). Location of algae had no effect at 500 μg/mL and 1000 μg/mL, while STW-QD (algae collected from Qingdao, China) had the best activity, followed by STW-WZ (algae collected from Wenzhou, China) and STW-LJ (algae collected from Lianjiang, China) and then STW-DL (algae collected from Dalian, China) and STW-RC (algae collected from Rongcheng, China) at 250 μg/mL. Moreover, molecular weight had no effect at 1000 μg/mL, while higher molecular weights were associated with better activities at 250 μg/mL and 500 μg/mL. Sulfate content had no effect at 1000 μg/mL, while anti-tumor activities decreased accompanying with the changes of sulfate content. Uronic acid content was an important factor influencing activity. The fractions of STW showed little anti-tumor activity; however, the mixture of the fractions of STW showed approximately 60% inhibition. Overall, these findings suggested that the anti-tumor activity of polysaccharides required multilateral cooperation and that some of the effective components were lost.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 105, Part 1, December 2017, Pages 686-692
نویسندگان
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