کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8330710 | 1540240 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bio-mimetic composite scaffold from mussel shells, squid pen and crab chitosan for bone tissue engineering
ترجمه فارسی عنوان
داربست کامپوزیتی بیومیدیک از پوسته های گوشتی، قلم ماهی مرکب و کیتوزان خرچنگ برای مهندسی بافت استخوان
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کلمات کلیدی
قلم ماهی مرکب، کیتوزان، هیدروکسی آپاتیت،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
In the present study, chitosan/hydroxyapatite (HA)/β-tircalcium phosphate (β-TCP) composites were produced using squid pen derived chitosan (CHS) and commercial crab derived chitosan (CHC). CHS was prepared from squid pens by alkaline N-deacetylation. HA and β-TCP were extracted from mussel shells using a microwave irradiation method. Two different composites were prepared by incorporating 50% (w/w) HA/(β-TCP) in CHS or CHC followed by lyophilization and cross-linking of composites by tripolyphosphate (TPP). The effect of different freezing temperatures of â20, â80 and â196 °C on the physicochemical characteristics of composites was investigated. A simulated body fluid (SBF) solution was used for preliminary in vitro study for 1, 7, 14 and 28 days and the composites were characterized by XRD, FTIR, TGA, SEM, μ-CT and ICP-MS. Porosity, pore size, water uptake; water retention abilities and in vitro degradations of the prepared composites were evaluated. The CHS composites were found to have higher porosity (62%) compared to the CHC composites (porosity 42%) and better mechanical properties. The results of this study indicated that composites produced at â20 °C had higher mechanical properties and lower degradation rate compared with â80 °C. Chitosan from the squid pen is an excellent biomaterial candidate for bone tissue engineering applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 80, September 2015, Pages 445-454
Journal: International Journal of Biological Macromolecules - Volume 80, September 2015, Pages 445-454
نویسندگان
Amin Shavandi, Alaa El-Din A. Bekhit, M. Azam Ali, Zhifa Sun,