کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8332644 | 1540248 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dietary Astragalus polysaccharide alleviated immunological stress in broilers exposed to lipopolysaccharide
ترجمه فارسی عنوان
رژیم غذایی استرادیول پلی ساکارید باعث کاهش استرس ایمونولوژیک در جوجه های گوشتی شده در معرض لیپوپلی ساکارید
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کلمات کلیدی
استراز پلازاکارد، استرس ایمونولوژیک، جوجه گوشتی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
This study was conducted to investigate whether dietary Astragalus polysaccharide (APS) could alleviate immunological stress response of chickens after challenge with lipopolysaccharide (LPS). A total of 360 one-day-old commercial Arbor Acres broilers were randomly assigned in a 2 Ã 2 factorial design. The main factors were immunological stress (LPS or saline) and dietary APS (0 or 3 g APS/kg feed). At 12, 14, 33 and 35 days of age, chickens were injected intramuscularly with either 500 μg/kg body weight of LPS or sterile saline. The results showed that the decreased daily feed intake and daily weight gain caused by immunological stress were dramatically attenuated by APS supplementation. The LPS challenge led to an increased mRNA abundance of TLR4, NF-κB, IL-1β, IL-6, avian uncoupling protein, α1-acid glycoprotein, hemopexin and y+LAT2. However, these negative effects of the LPS administration were ameliorated by APS supplementation. Moreover, dietary APS inhibited the LPS-induced depression of amino acid digestibilities. In conclusion, APS is able to alleviate LPS-induced immunological stress response in chickens. The beneficial effect may be attributed to suppressing the expression of pro-inflammatory cytokines through reducing the TLR4 and NF-κB genes transcription, and therewith improving energy and protein metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 72, January 2015, Pages 624-632
Journal: International Journal of Biological Macromolecules - Volume 72, January 2015, Pages 624-632
نویسندگان
Lei Liu, Jing Shen, Chao Zhao, Xiaofei Wang, Junhu Yao, Yuesheng Gong, Xiaojun Yang,