کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8333818 | 1540263 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mimosa pudica seed mucilage: Isolation; characterization and evaluation as tablet disintegrant and binder
ترجمه فارسی عنوان
موش خاکستر میگوس پودیکا: جداسازی؛ توصیف و ارزیابی به عنوان تکه کننده و گیربکس
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
In the present study Mimosa pudica seed mucilage was isolated, characterized and evaluated as tablet binder and disintegrant. Several properties of mucilage like high swelling index and gelling nature prompted us to explore its applications as disintegrating and binding agent. Disintegrant properties were evaluated by formulating directly compressed hydrochlorothiazide tablets containing 1%-10% (w/w) of seed mucilage as disintegrant and compared with the standard disintegrants. The disintegration time of mucilage containing tablets was found to be in the order of 3% > 1% > 5% > 7.5% > 10%. On comparative evaluation with standard disintegrants, it was observed that the order of disintegration of tablets was Ac-Di-Sol < mucilage (3%, w/w) < corn starch. The results of liquid uptake studies were consistent with the disintegration time studies. The binding and granulating properties of mucilage were evaluated by formulating the paracetamol tablets using the Mimosa mucilage at 6%, 8%, and 10% (w/w) concentration as the binder and compared with tablets prepared using PVP-K25 (1.7%, w/w) and acacia (6.8%, w/w) as the binder. Mimosa mucilage at 10% (w/w) concentration provided tablets with adequate hardness and friability. In conclusion, M. pudica seed mucilage is a potential tablet disintegrant and binder.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 57, June 2013, Pages 105-110
Journal: International Journal of Biological Macromolecules - Volume 57, June 2013, Pages 105-110
نویسندگان
Munish Ahuja, Ashok Kumar, Parvinder Yadav, Kuldeep Singh,