کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8333894 | 1540263 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Trivalent ion cross-linked pH sensitive alginate-methyl cellulose blend hydrogel beads from aqueous template
ترجمه فارسی عنوان
دانه های هیدروژل مخلوط آلژینات-متیل سلولز از فرمول آب
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کلمات کلیدی
روش ژله سازی امولسیون، سلولز متیل، آلژینات، یون سه گانه، دانه های هیدروژل،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
pH sensitive alginate-methyl cellulose blend hydrogel beads were prepared by single water-in-water (w/w) emulsion gelation method in a complete aqueous environment. The influence of different variables like total polymer concentration, gelation time and crosslinker content on in vitro physico-chemical characteristics and drug release rate in different medium were investigated. Drug loaded beads were evaluated through Fourier Transform Infra-red (FTIR), X-ray diffraction (XRD) and Differential Scanning Calorimetry (DSC) analysis. Scanning electron microscopy (SEM) picture of the dried beads suggested the formation of hemispherical particles. FTIR analysis indicated the stable nature of the drug in the blend hydrogel beads. DSC and XRD analysis revealed amorphous state of drug after encapsulation. The drug release profile in acidic medium was considerably less in compared in alkaline media. Formulations showed non-Fickian type transport mechanism. This trivalent ion crosslinked beads not only improves drug encapsulation efficiency but also enhances drug release in alkaline media.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 57, June 2013, Pages 297-307
Journal: International Journal of Biological Macromolecules - Volume 57, June 2013, Pages 297-307
نویسندگان
Subham Banerjee, Shivangi Singh, Shiv Sankar Bhattacharya, Pronobesh Chattopadhyay,