کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8334501 | 1540272 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibitory effects of naphthols on the activity of mushroom tyrosinase
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کلمات کلیدی
IC50L-TyrDMSO - DMSOl-3,4-dihydroxyphenylalanine - L-3،4-دی هیدروکسی فنیل آلانینl-DOPA - L-DOPAl-Tyrosine - L-TyrosineTyrosinase - تیروزیناز Inhibition kinetics - جنبش مهارDimethyl sulfoxide - دیمتیل سولفواکسیدDiphenolase activity - فعالیت دیفنولازMonophenolase activity - فعالیت مونوفنولازNaphthol - نفتول
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inhibitory effects of naphthols on the activity of mushroom tyrosinase Inhibitory effects of naphthols on the activity of mushroom tyrosinase](/preview/png/8334501.png)
چکیده انگلیسی
Tyrosinase (EC 1.14.18.1), a copper-containing multifunctional oxidase, was known to be a key enzyme for biosynthesis in fungi, plants and animals. In this work, the inhibition properties α-naphthol and β-naphthol toward the activity of tyrosinase have been evaluated, and the effects of α-naphthol and β-naphthol on monophenolase and diphenolase activity of tyrosinase have been investigated. The results showed that both α-naphthol and β-naphthol could potently inhibit both monophenolase activity and diphenolase activity of mushroom tyrosinase, and that β-naphthol exhibited stronger inhibitory effect against tyrosinase than α-naphthol. For monophenolase activity, β-naphthol could not only lengthen the lag time but also decrease the steady-state activity, while α-naphthol just only decreased the steady-state activity. For diphenolase activity, both α-naphthol and β-naphthol displayed revisible inhibition. Kinetic analyses showed that both α-naphthol and β-naphthol were competetive inhibitors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 51, Issues 1â2, JulyâAugust 2012, Pages 32-36
Journal: International Journal of Biological Macromolecules - Volume 51, Issues 1â2, JulyâAugust 2012, Pages 32-36
نویسندگان
Yi-Fen Lin, Yong-Hua Hu, Yu-Long Jia, Zhi-Cong Li, Yun-Ji Guo, Qing-Xi Chen, He-Tong Lin,