Enhanced delivery of baicalein using cinnamaldehyde cross-linked chitosan nanoparticle inducing apoptosis

► The baicalein loaded chitosan nanoparticles was synthesized using cinnamaldehyde as crosslinking agent. ► The evaluation of anti-cancer activity of baicalein loaded chitosan nanoparticles was carried out. ► The experiment conducted revealed that the synthesized nanoparticles had good loading and encapsulation efficiency value. ► The RT-PCR result showed the caspase activity involved. ► The evaluation of apoptosis in MCF7 cell lines by Baicalein loaded chitosan nanoparticles showed good activity.