کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8335485 | 1540278 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex](/preview/png/8335485.png)
چکیده انگلیسی
An algal extracellular biopolymer (over 8.5Â ÃÂ 105Â Da) composed of carbohydrates (52%) and protein (â¼13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer contained xylose and its 3-O- and 4-O-methyl derivatives (â¼63%), galactose (â¼12%), glucuronic acid (11-12%), glucose (â¼5%), rhamnose (â¼4%), fucose (â¼3-4%) and low content of others accompaning sugars. When tested on the citric acid-induced cough and reactivity of airways smooth muscle in vivo in the test system guinea pigs, this biopolymer assigned a significant cough suppressing effect. The reactivity of airways smooth muscle was not affected indicating that expectoration effect was not suppressed by biopolymer application, which is important from the pharmacological point of view.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 49, Issue 5, 1 December 2011, Pages 1046-1050
Journal: International Journal of Biological Macromolecules - Volume 49, Issue 5, 1 December 2011, Pages 1046-1050
نویسندگان
G. Nosáľová, P. Capek, D. FleÅ¡ková, Ľ. JureÄek, F. Hindák, J. Lukavský, V. Cepák, B. Ray, E. Breierová, J. Turjan,