کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8337261 | 1540666 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Grape skin extract protects against programmed changes in the adult rat offspring caused by maternal high-fat diet during lactation
ترجمه فارسی عنوان
عصاره پوست انگور در برابر تغییرات برنامه ریزی شده در فرزندان موش بالغ ناشی از رژیم غذایی با رژیم غذایی مادر در طول شیردهی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
عصاره پوست انگور فشار خون، مقاومت به انسولین، استرس اکسیداتیو، برنامه ریزی توسعه،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Maternal overnutrition during suckling period is associated with increased risk of metabolic disorders in the offspring. We aimed to assess the effect of Vitis vinifera L. grape skin extract (ACH09) on cardiovascular and metabolic disorders in adult male offspring of rats fed a high-fat (HF) diet during lactation. Four groups of female rats were fed: control diet (7% fat), ACH09 (7% fat plus 200 mg kgâ1 dâ1 ACH09 orally), HF (24% fat), and HF+ACH09 (24% fat plus 200 mg kgâ1 dâ1 ACH09 orally) during lactation. After weaning, all male offspring were fed a control diet and sacrificed at 90 or 180 days old. Systolic blood pressure was increased in adult offspring of HF-fed dams and ACH09 prevented the hypertension. Increased adiposity, plasma triglyceride, glucose levels and insulin resistance were observed in offspring from both ages, and those changes were reversed by ACH09. Expression of insulin cascade proteins IRS-1, AKT and GLUT4 in the soleus muscle was reduced in the HF group of both ages and increased by ACH09. The plasma oxidative damage assessed by malondialdehyde levels was increased, and nitrite levels decreased in the HF group of both ages, which were reversed by ACH09. In addition, ACH09 restored the decreased plasma and mesenteric arteries antioxidant activities of superoxide dismutase, catalase and glutathione peroxidase in the HF group. In conclusion, the treatment of HF-fed dams during lactation with ACH09 provides protection from later-life hypertension, body weight gain, insulin resistance and oxidative stress. The protective effect ACH09 may involve NO synthesis, antioxidant action and activation of insulin-signaling pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 24, Issue 12, December 2013, Pages 2119-2126
Journal: The Journal of Nutritional Biochemistry - Volume 24, Issue 12, December 2013, Pages 2119-2126
نویسندگان
Angela C. Resende, Andréa F. Emiliano, Viviane S.C. Cordeiro, Graziele F. de Bem, Lenize C.R.M. de Cavalho, Paola Raquel B. de Oliveira, Miguel L. Neto, Cristiane A. Costa, Gilson T. Boaventura, Roberto S. de Moura,