The vitamin D analog TX527 ameliorates disease symptoms in a chemically induced model of inflammatory bowel disease

▸ The vitamin D analog TX527 decreases disease symptoms in a model of inflammatory bowel disease. ▸ TX527 treatment results in reduced damage and immune infiltration in the colon of diseased animals. ▸ TX527 treatment leads to reduced transcription of inflammatory cytokines in animals with IBD. ▸ Oxidative stress in the colon is decreased when animals with IBD are treated with TX527.