Histone deacetylation mediates the rejuvenation of osteoblastogenesis by the combination of 25(OH)D3 and parathyroid hormone in MSCs from elders

▸ The pro-differentiation and anti-proliferative effects of 1α,25(OH)2D in human marrow stromal cells (MSCs) required VDR. ▸ With age there are declines in osteoblast differentiation of human MSCs and in its stimulation by 25(OH)D. ▸ 25(OH)D3 and PTH act synergistically to stimulate osteoblastogenesis in MSCs from elders. ▸ Histone deacetylation is required for the synergistic effect of 25(OH)D3 and PTH. ▸ Epigenetic regulation of VDR may rejuvenate osteoblastogenesis in hMSCs of elders.