1α,25-Dihydroxyvitamin D3 and its analogs as modulators of human dendritic cells: A comparison dose-titration study

▸ 1α,25(OH)2 D3 and TX527 similarly inhibit DC differentiation and maturation at higher doses (10−7 M and 10−8 M). ▸ TX527 is a more immunopotent analog of 1α,25(OH)2D3 at more physiological doses (10−10 M). ▸ Different maturation triggers do not differentially affect the outcome of 1α,25(OH)2D3 or TX527 treatment. ▸ Increase in ROS production by 1α,25(OH)2D3 or TX527 does not adversely affect cell survival.