Differential effects of 1,25-dihydroxyvitamin D on mineralisation and differentiation in two different types of osteoblast-like cultures

▸ Osteoblast-like cell cultures demonstrate variable degrees of cell maturation. ▸ 1,25D promotes pro-catabolic and anti-anabolic responses only in immature osteoblast-like cells. ▸ 1,25D inhibits mineral deposition only in immature osteoblast-like cell cultures.