Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells

▸ mRNA regulation for VDR target genes differs between non-malignant and malignant prostate models. ▸ NCOR1 is selectively recruited to genes such as IGFBP3 which are repressed by VDR activation in prostate cancer cells. ▸ These findings underline the complex and gene-selective nature by which VDR actions are distorted in cancer cells.