Protective role of vitamin D signaling in skin cancer formation

▸ Skin cancer is the most common type of malignancy. ▸ UVB is the primary etiologic agent inducing skin cancer. ▸ UVB is required for vitamin D production in the skin. ▸ Vitamin D and its receptor provide protection against UVB induced skin cancer. ▸ This protection involves inhibition of proliferation, stimulation of differentiation, immune regulation, and DNA repair.