Prevention of preneoplastic lesions by dietary vitamin D in a mouse model of colorectal carcinogenesis

▸ High dietary vitamin D was able to prevent premalignant lesions caused by AOM/DSS. ▸ Increasing vitamin D intake raised serum 25-D3 levels reaching a plateau ≥1000 IU/kg. ▸ Serum 25-D3 levels over 30 ng/ml are needed to prevent tumorigenesis.