1,25-Dihydroxyvitamin D3-glycoside of herbal origin exhibits delayed release pharmacokinetics when compared to its synthetic counterpart

▸ A different pharmacokinetic profile after application of a Solanum glaucophyllum extract, compared to synthetic 1,25-dihydroxyvitamin D3. ▸ The extract was characterized by its main components and contains 1,25-dihydroxyvitamin D3-glycosides as the active components. ▸ The differences were seen after a single and after multiple applications. ▸ After multiple applications the known up-regulated elimination of 1,25-dihydroxyvitamin D3 was less pronounced in the SG extract.