Minireview: PPARγ as the target of obesogens

► Inappropriate activation of PPARγ by environmental chemicals contributes to obesity. ► Many natural products activate PPARγ but are not necessarily linked to adipogenesis. ► PPARγ is a vulnerable target of obesogens during prenatal programming events. ► Obesogens could alter lineage-specific histone modifications in stem cells. ► Obesogens could bias PPARγ towards recruitment to adipogenic gene enhancers.