Clinical steroid mass spectrometry: A 45-year history culminating in HPLC-MS/MS becoming an essential tool for patient diagnosis

FAB transformed biological mass spectrometry in the 1980s but in the end was an interim technique; GC/MS retains unique qualities but is unsuited to commercial routine analysis, while LC-MS/MS is rightly stealing the show and has become the dominant method for steroid analysis in endocrinology.