کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8339823 1541045 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulatory T cells, inflammation and the allergic response-The role of glucocorticoids and Vitamin D
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Regulatory T cells, inflammation and the allergic response-The role of glucocorticoids and Vitamin D
چکیده انگلیسی
Regulatory T cells (TRegs) play a central role in the maintenance of peripheral tolerance. They prevent inappropriate immune responses to ubiquitous allergens in healthy individuals, and contribute to the maintenance of immune homeostasis in the airways. Both Foxp3+ and IL-10+ TReg have been implicated in these functions. Glucocorticoids represent the mainstay of treatment for asthma and other allergic conditions, and evidence that steroids influence TReg function will be reviewed. Growing bodies of epidemiological and immunological data suggest a role for endogenous Vitamin D in immune regulation. This review will discuss the role of glucocorticoids and Vitamin D, and their potential interactions in promoting tolerance in the context of allergic disease and asthma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 120, Issues 2–3, 31 May 2010, Pages 86-95
نویسندگان
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