The anti-HIV-1 activity of polyphenols from Phyllanthus urinaria and the pharmacokinetics and tissue distribution of its marker compound, gallic acid

A PE isolated from P. urinaria containing GA has anti-HIV-1 activities. GA is quickly absorbed and slowly eliminated in rats after oral administration. The pharmacokinetics of GA administered as a PE is desirable, and it is widely distributed in the main tissues of lung and liver. Both its properties and anti-HIV-1 activities make it of interest for further studies.