کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8340163 1541197 2017 33 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In silico methods for design of biological therapeutics
ترجمه فارسی عنوان
در روش های سیلیکا برای طراحی درمان های بیولوژیکی
کلمات کلیدی
بیوتراپی، طراحی پروتئین / پپتید، در مهندسی سیلیکا از آنتی بادی ها و واکسن ها،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
It has been twenty years since the first rationally designed small molecule drug was introduced into the market. Since then, we have progressed from designing small molecules to designing biotherapeutics. This class of therapeutics includes designed proteins, peptides and nucleic acids that could more effectively combat drug resistance and even act in cases where the disease is caused because of a molecular deficiency. Computational methods are crucial in this design exercise and this review discusses the various elements of designing biotherapeutic proteins and peptides. Many of the techniques discussed here, such as the deterministic and stochastic design methods, are generally used in protein design. We have devoted special attention to the design of antibodies and vaccines. In addition to the methods for designing these molecules, we have included a comprehensive list of all biotherapeutics approved for clinical use. Also included is an overview of methods that predict the binding affinity, cell penetration ability, half-life, solubility, immunogenicity and toxicity of the designed therapeutics. Biotherapeutics are only going to grow in clinical importance and are set to herald a new generation of disease management and cure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Methods - Volume 131, 1 December 2017, Pages 33-65
نویسندگان
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