کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8340448 1541233 2016 23 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pushing the annotation of cellular activities to a higher resolution: Predicting functions at the isoform level
ترجمه فارسی عنوان
قرار دادن حاشیه نویسی فعالیت های سلولی به وضوح بالاتر: پیش بینی عملکرد در سطح ایزوفرم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
In past decades, the experimental determination of protein functions was expensive and time-consuming, so numerous computational methods were developed to speed up and guide the process. However, most of these methods predict protein functions at the gene level and do not consider the fact that protein isoforms (translated from alternatively spliced transcripts), not genes, are the actual function carriers. Now, high-throughput RNA-seq technology is providing unprecedented opportunities to unravel protein functions at the isoform level. In this article, we review recent progress in the high-resolution functional annotations of protein isoforms, focusing on two methods developed by the authors. Both methods can integrate multiple RNA-seq datasets for comprehensively characterizing functions of protein isoforms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Methods - Volume 93, 15 January 2016, Pages 110-118
نویسندگان
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