کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8340892 | 1541266 | 2018 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Microvascular abnormalities in dry eye patients
ترجمه فارسی عنوان
اختلالات میکروویروس در بیماران چشم خشک
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
This study was conducted to evaluate conjunctival blood flow velocities and microvascular network density in patients with dry eye disease (DED). Twenty-five patients with DED and 25 healthy controls were recruited. The microvasculature and microcirculation of the temporal bulbar conjunctiva of the right eyes were assessed using a functional slit-lamp biomicroscope. Vascular variables included blood flow velocity (BFV), blood flow rate (BFR), microvascular network density and vessel diameter. A fractal analysis was performed using the box counting method to measure the fractal dimension (Dbox) representing the vessel density. The bulbar BFV was 0.59â¯Â±â¯0.09â¯mm/s in the DED group and 0.47â¯Â±â¯0.12 in the control group (Pâ¯<â¯0.001). BFR was 169.5â¯Â±â¯1.8 in the DED group compared to the control group (107.2â¯Â±â¯49.6) (Pâ¯<â¯0.001). Dbox was higher in DED patients (1.65â¯Â±â¯0.04) than controls (1.60â¯Â±â¯0.07, Pâ¯<â¯0.05). Moreover, the vessel diameter was larger in the DED group (21.8â¯Â±â¯1.8â¯Î¼m) compared with controls (17.9â¯Â±â¯2.2â¯Î¼m, Pâ¯<â¯0.001). Dbox was positively related with ocular surface disease index (OSDI) in patients with DED (râ¯=â¯0.54, Pâ¯=â¯0.008). Microvascular alterations were found in the bulbar conjunctiva of DED patients, including increased blood flow velocity, higher vessel density and larger vessel diameter.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 118, July 2018, Pages 155-161
Journal: Microvascular Research - Volume 118, July 2018, Pages 155-161
نویسندگان
Wan Chen, Yuqing Deng, Hong Jiang, Jianhua Wang, Jing Zhong, Saiqun Li, Lulu Peng, Bowen Wang, Ruhui Yang, Henan Zhang, Meng Li, Jin Yuan,