کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8341424 1541426 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extracellular vesicles: Novel mediator for cell to cell communications in liver pathogenesis
ترجمه فارسی عنوان
حامل های خارج سلولی: واسطه ای نوین برای ارتباطات سلولی و سلولی در پاتوژنز کبد
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Extracellular vesicles (EVs) are membrane derived nanometer-sized vesicles. EVs are released by normal, diseased, and transformed cells in vitro and in vivo, and carry lipids, proteins, mRNAs, non-coding RNAs, and even DNA out of cells. Transferring biological information via EVs to neighboring cells and inter-cellular communication not only maintain physiological functions, but also involve in the pathogenesis of several diseases, including cancer. The aim of this review is to discuss the emerging role of EVs in viral hepatitis, non-alcoholic or alcoholic liver disease and liver cancers. We summarize what is known about exosome biogenesis, and role in liver disease progression, and discuss the potential clinical applications of EVs as predictive biomarkers and therapeutic modalities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Aspects of Medicine - Volume 60, April 2018, Pages 115-122
نویسندگان
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