An exploratory study of brain function and structure in mucopolysaccharidosis type I: Long term observations following hematopoietic cell transplantation (HCT)

► Attention problems were found in MPS IH compared to attenuated MPSI. ► Fractional anisotropy was lower in MPS IH than in attenuated MPS. ► Fractional anisotropy was associated with attention problems in MPS IH. ► Fractional anisotropy was associated with frequency of medical events. ► Transplant and disease severity affect white matter connectivity and attention.