کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8344409 | 1541580 | 2018 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inorganic nitrate supplementation enhances functional capacity and lower-limb microvascular reactivity in patients with peripheral artery disease
ترجمه فارسی عنوان
مکمل نیترات معدنی افزایش ظرفیت عملکردی و واکنش پذیری میکروواسکولار پایین لبه در بیماران مبتلا به بیماری شریان های محیطی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
بیماری شریانی محیطی، عملکرد عروقی، ظرفیت ورزش، نیترات معدنی، اکسید نیتریک،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Peripheral artery disease (PAD) is characterized by functional and vascular impairments as well as elevated levels of inflammation which are associated with reduced nitric oxide (NO) bioavailability. Inorganic nitrate supplementation boosts NO bioavailability potentially improving functional and vasodilatory capacities and may reduce inflammation. Twenty-one patients with PAD were randomly assigned to sodium nitrate (NaNO3) or placebo supplementation groups for eight-weeks. Outcome measures included a 6-min walk test (6â¯MWT), blood flow and vasodilator function in the forearm and calf, as well as plasma inflammatory and adhesion biomarker concentrations. NaNO3 elevated plasma nitrate (32.3â¯Â±â¯20.0 to 379.8â¯Â±â¯204.6â¯Î¼M) and nitrite (192.2â¯Â±â¯51.8 to 353.1â¯Â±â¯134.2â¯nM), improved 6â¯MWT performance (387â¯Â±â¯90 to 425â¯Â±â¯82â¯m), peak calf blood flow (BFPeak; 11.6â¯Â±â¯4.9 to 14.1â¯Â±â¯5.1â¯mL/dLâ¯tissue/min), and peak calf vascular conductance (VCPeak; 11.1â¯Â±â¯4.3 to 14.2â¯Â±â¯4.9â¯mL/dLâ¯tissue/min/mmHg) (pâ¯<â¯0.05 for all). Improvements in calf BFPeak (râ¯=â¯0.70, pâ¯<â¯0.05) and VCPeak (râ¯=â¯0.61, pâ¯<â¯0.05) correlated with changes in 6â¯MWT distance. Placebo supplementation did not change plasma nitrate or nitrite, 6â¯MWT, calf BFPeak, or calf VCPeak. Forearm vascular function nor inflammatory and adhesion biomarker concentrations changed in either group. Eight-weeks of NaNO3 supplementation improves vasodilatory capacity in the lower-limbs of patients with PAD, which correlated with improvement in functional capacity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nitric Oxide - Volume 80, 1 November 2018, Pages 45-51
Journal: Nitric Oxide - Volume 80, 1 November 2018, Pages 45-51
نویسندگان
Joshua M. Bock, David P. Treichler, Samuel L. Norton, Kenichi Ueda, William E. Hughes, Darren P. Casey,