کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8344795 | 1541600 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Detection and removal of impurities in nitric oxide generated from air by pulsed electrical discharge
ترجمه فارسی عنوان
تشخیص و حذف ناخالصی ها در اکسید نیتریک تولید شده توسط هوا توسط تخلیه الکتریکی پالس
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کلمات کلیدی
اکسید نیتریک، تخلیه الکتریکی پالسی ذرات فلزی، الکترود ایریدیم،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Inhalation of nitric oxide (NO) produces selective pulmonary vasodilation without dilating the systemic circulation. However, the current NO/N2 cylinder delivery system is cumbersome and expensive. We developed a lightweight, portable, and economical device to generate NO from air by pulsed electrical discharge. The objective of this study was to investigate and optimize the purity and safety of NO generated by this device. By using low temperature streamer discharges in the plasma generator, we produced therapeutic levels of NO with very low levels of nitrogen dioxide (NO2) and ozone. Despite the low temperature, spark generation eroded the surface of the electrodes, contaminating the gas stream with metal particles. During prolonged NO generation there was gradual loss of the iridium high-voltage tip (â90 μg/day) and the platinum-nickel ground electrode (â55 μg/day). Metal particles released from the electrodes were trapped by a high-efficiency particulate air (HEPA) filter. Quadrupole mass spectroscopy measurements of effluent gas during plasma NO generation showed that a single HEPA filter removed all of the metal particles. Mice were exposed to breathing 50 parts per million of electrically generated NO in air for 28 days with only a scavenger and no HEPA filter; the mice did not develop pulmonary inflammation or structural changes and iridium and platinum particles were not detected in the lungs of these mice. In conclusion, an electric plasma generator produced therapeutic levels of NO from air; scavenging and filtration effectively eliminated metallic impurities from the effluent gas.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nitric Oxide - Volume 60, 30 November 2016, Pages 16-23
Journal: Nitric Oxide - Volume 60, 30 November 2016, Pages 16-23
نویسندگان
Binglan Yu, Aron H. Blaesi, Noel Casey, Grigory Raykhtsaum, Luca Zazzeron, Rosemary Jones, Alexander Morrese, Danil Dobrynin, Rajeev Malhotra, Donald B. Bloch, Lee E. Goldstein, Warren M. Zapol,