کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8345904 1541624 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phosphodiesterase 5 as target for adipose tissue disorders
ترجمه فارسی عنوان
فسفودی استراز 5 به عنوان هدف برای اختلالات بافت چربی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
IntroductionAdipose tissue as an endocrine organ is responsible for the release of multiple cytokines, which have the most diverse metabolic functions. Therefore, it is extremely important to preserve its physiological health in order to avoid local and systemic disorders. Experiments available in literature show the importance of the nitric oxide (NO)/guanosine 3′5′ cyclic monophosphate (cGMP)/protein kinase G (PKG) pathway in adipocyte biology. Phosphodiesterase 5 (PDE5) is an enzyme responsible for cGMP inactivation, and the use of its inhibitors can be an alternative in the search of a more balanced adipose tissue.ObjectiveThis review aims to describe the PDE5 role and the possibility of using PDE5 inhibitors in adipocyte physiology derangements and their consequences.Design and methodsStudies published in the last 10 years that related PDE5 and its inhibitors to adipose tissue were raised in major databases.ResultsPDE5 is present in adipocyte, and PDE5 inhibitors can promote adipogenesis, interfere with adipokines secretion, decrease inflammatory markers expression, and increase the thermogenic potential of white adipose tissue.ConclusionsPDE5 plays an important role in adipocyte physiology and the use of its inhibitors may prove a useful tool to combat adipose tissue disorders and its highest expression, metabolic syndrome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nitric Oxide - Volume 35, 30 November 2013, Pages 186-192
نویسندگان
, , , ,