کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8345970 | 1541624 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of a nitrate-rich meal on arterial stiffness and blood pressure in healthy volunteers
ترجمه فارسی عنوان
تأثیر یک وعده غذایی غنی از نیترات بر سختی شریان و فشار خون در داوطلبان سالم
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
An increase in nitrate intake can augment circulating nitrite and nitric oxide. This may lead to lower blood pressure and improved vascular function. Green leafy vegetables, such as spinach, are rich sources of nitrate. We aimed to assess the acute effects of a nitrate-rich meal containing spinach on arterial stiffness and blood pressure in healthy men and women. Twenty-six participants aged 38-69Â years were recruited to a randomized controlled cross-over trial. The acute effects of two energy-matched (2000Â kJ) meals, administered in random order, were compared. The meals were either high nitrate (220Â mg of nitrate derived from spinach [spinach]) or low nitrate [control]. Outcome measurements were performed pre-meal and at specific time points up to 210Â min post meal. Spinach resulted in an eightfold increase in salivary nitrite and a sevenfold increase in salivary nitrate concentrations from pre-meal (PÂ <Â 0.001) to 120Â min post meal. Spinach compared with control resulted in higher large artery elasticity index (PÂ <Â 0.001), and lower pulse pressure (PÂ <Â 0.001) and systolic blood pressure (PÂ <Â 0.001). Post meal carotid-femoral pulse wave velocity (PÂ =Â 0.07), augmentation index (PÂ =Â 0.63), small artery elasticity index (PÂ =Â 0.98) and diastolic blood pressure (PÂ =Â 0.13) were not significantly altered by spinach relative to control. Therefore, consumption of a nitrate-rich meal can lower systolic blood pressure and pulse pressure and increase large artery compliance acutely in healthy men and women. If sustained, these effects could contribute to better cardiovascular health.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nitric Oxide - Volume 35, 30 November 2013, Pages 123-130
Journal: Nitric Oxide - Volume 35, 30 November 2013, Pages 123-130
نویسندگان
Alex H. Liu, Catherine P. Bondonno, Kevin D. Croft, Ian B. Puddey, Richard J. Woodman, Lisa Rich, Natalie C. Ward, Joseph A. Vita, Jonathan M. Hodgson,